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Function Spaces, 2

為了解決Functional的問題，作者Pick, Lubos,Musil, Vit,Kufner, Alois 這樣論述：

The series is devoted to the publication of high-level monographs which cover the whole spectrum of current nonlinear analysis and applications in various fields, such as optimization, control theory, systems theory, mechanics, engineering, and other sciences. One of its main objectives is to mak

e available to the professional community expositions of results and foundations of methods that play an important role in both the theory and applications of nonlinear analysis. Contributions which are on the borderline of nonlinear analysis and related fields and which stimulate further research a

t the crossroads of these areas are particularly welcome. Editor-in-ChiefJürgen Appell, Würzburg, Germany Honorary and Advisory EditorsCatherine Bandle, Basel, SwitzerlandAvner Friedman, Columbus, Ohio, USAManuel del Pino, Bath, UK, and Santiago, ChileMikio Kato, Nagano, JapanWojciech Kryszewski, To

ruń, PolandVicenţiu D. Rădulescu, Kraków, PolandSimeon Reich, Haifa, Israel Please submit book proposals to Jürgen Appell. Titles in planning includeIreneo Peral Alonso and Fernando Soria, Elliptic and Parabolic Equations Involving the Hardy-Leray Potential (2020)Cyril Tintarev, Profile Decompositio

ns and Cocompactness: Functional-Analytic Theory of Concentration Compactness (2020)Takashi Suzuki, Semilinear Elliptic Equations: Classical and Modern Theories (2021)

Functional進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Functional的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Function Spaces, 1

為了解決Functional的問題，作者Pick, Lubos,Musil, Vit,Kufner, Alois 這樣論述：

The series is devoted to the publication of high-level monographs which cover the whole spectrum of current nonlinear analysis and applications in various fields, such as optimization, control theory, systems theory, mechanics, engineering, and other sciences. One of its main objectives is to mak

e available to the professional community expositions of results and foundations of methods that play an important role in both the theory and applications of nonlinear analysis. Contributions which are on the borderline of nonlinear analysis and related fields and which stimulate further research a

t the crossroads of these areas are particularly welcome. Editor-in-ChiefJürgen Appell, Würzburg, Germany Honorary and Advisory EditorsCatherine Bandle, Basel, SwitzerlandAvner Friedman, Columbus, Ohio, USAManuel del Pino, Bath, UK, and Santiago, ChileMikio Kato, Nagano, JapanWojciech Kryszewski, To

ruń, PolandVicenţiu D. Rădulescu, Kraków, PolandSimeon Reich, Haifa, Israel Please submit book proposals to Jürgen Appell. Titles in planning includeIreneo Peral Alonso and Fernando Soria, Elliptic and Parabolic Equations Involving the Hardy-Leray Potential (2020)Cyril Tintarev, Profile Decompositio

ns and Cocompactness: Functional-Analytic Theory of Concentration Compactness (2020)Takashi Suzuki, Semilinear Elliptic Equations: Classical and Modern Theories (2021)

以線上三級介入模式提升國中普通班教師正向行為支持知識之研究

為了解決Functional的問題，作者潘淳威 這樣論述：

本研究目的為探討以線上三級介入模式提升國中普通班教師正向行為支持知識之成效以及看法。研究方法採單一受試實驗之變更情境設計，以6名國中普通班教師為研究參與者，採用三級介入模式進行線上培訓，依序以自學、團體工作坊、一對一教練方式進行，每一階段評量結果未達90%之參與者進入下一階段接受介入，介入完成後填寫回饋調查。將所蒐集之量化資料進行視覺分析，並統整參與者回饋等相關質性資料，得到以下發現。一、 以線上三級介入模式實施正向行為支持課程，有2位教師能在次級達通過標準。二、 以線上三級介入模式實施正向行為支持課程，可提升6位教師正向行為支持的知識，其中2位教師達通過標準。三、 5位教師認同以行為技能訓

練融入教材與教學有助於學習與操作，4位教師對本教材持肯定態度。四、 4位教師認同線上三級模式可提供他們在學習上不同程度的支持、能滿足其學習風格與偏好。五、 4位教師認為正向行為支持對處理學生行為問題有幫助，願意在未來使用，並有信心能預防行為問題。