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The Night Before Christmas Pop Up Book: A Pop-Up Edition

為了解決Offer的問題，作者Moore, Clement 這樣論述：

This magnificent Christmas Eve poem is brought to life in this pop-up edition of the #1 New York Times best seller The Night Before Christmas. ’Twas the night before Christmas, when all through the house, Not a creature was stirring, not even a mouse... This holiday season enjoy everyone’s favor

ite Christmas Eve poem with this beautiful pop-up book. Every child knows the words to this captivating story, and this delightful edition provides an exciting 3D reading experience for children and parents alike. Join Dasher, Dancer, Prancer, Vixen, Comet, Cupid, Donder, and Blitzen and dash your w

ay through these dynamic pages. Not only will this Christmas poem spread holiday cheer, it will engage your child and encourage a love of reading. This edition includes: - 3D pop-up elements that offer a new take on this nostalgic Christmas classic - A beautifully designed hardcover with an embosse

d foil-stamped cover - Clement C. Moore’s original text, including a nod to Dutch references in the poem, specifically the Dutch name ＂Donder,＂ which translates to ＂thunder＂ - Stunning artwork by #1 New York Times best-selling illustrator Charles Santore. Start a new family tradition this year or

carry on your own with this illuminating edition of a timeless tale. You’ll be sharing this holiday classic with children and family for years to come. The work of New York Times bestselling children’s book illustrator Charles Santore has been widely exhibited in museums and celebrated with recognit

ions such as the prestigious Hamilton King Award, the Society of Illustrators Award of Excellence, and the Original Art 2000 Gold Medal from the Society of Illustrators. He is best known for his luminous interpretations of classic children’s stories, including The Little Mermaid, Alice’s Adventures

in Wonderland, Snow White, and The Wizard of Oz.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Offer的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

When the Truth Finds the Light: Finding the Courage to Keep Showing Up

為了解決Offer的問題，作者Doby, Danielle 這樣論述：

In this unique offering, The Unbound Body explores author Danielle Doby’s deeply personal journey with cancer through both poetry and memoir. Doby offers her insights on grief, joy, trauma, love, healing, and how one can move closer to life by choosing to offer their attention, staying present in

moment and body.At the young age of 34, and having spent three years traveling through the medical system in search of answers, Danielle Doby was given the news that she had an aggressive form of breast cancer. Everything she held to be true was thrown out of her grasp and scattered across the floo

r, down at her feet. What she didn’t know then, that she soon learned, a global pandemic was nearing, and much of the unknown that lay before her would need to be traveled alone. Doby’s intimate way of storytelling strives to answer the questions, What defines a miracle? And, when do you know you’v

e experienced one?

銀行、證券及保險動態併行效率評估

為了解決Offer的問題，作者陳軒頎 這樣論述：

本研究探討的是在台灣金控體系裡同時擁有銀行、證券及保險的金控公司，子公司的效率是如何影響金控本身，多元化的大型金控要如何去針對各子公司的弱項去強化，讓資源的運用更有效率。在過去的文獻中，發現擁有高效率的銀行比同行要更能抵擋金融危機，以及大型銀行較可能從規模經濟中獲益，多元經營的金控子公司可以從多元化的結構中獲得更多的收益，並且金控的子公司可以通過分擔風險以減少不良產出，這些文獻已經證實了大型且多元經營的銀行擁有比一般單純銀行更高的績效。在此前的研究缺少了保險部門的績效比較，對於以保險業為主的金控公司就顯得吃虧，本文要在這一基礎上更進一步，加入保險部門，並配合視窗分析法解決決策單元數量減少的問

題。透過同時分析金控公司底下的銀行、證券及保險子公司三個部門的績效，能夠解析金控內部這三個部門各自營運情形，結果更能貼近金融業真實情況，有利於決策管理人瞭解參考與決策。從結果中發現保險部門是這10家大型金控中較需改進的部門，但因保險業加入臺灣金融體系的時間還不夠長，盼將來的資料增加後能進行更完整更詳細的分析。