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The Wisdom of the Ages and the Secrets of the Sages: A Medieval Arabic Grimoire

為了解決Smoke的問題，作者Babylonian, Albusem the/ Klein, Darius (TRN) 這樣論述：

The Wisdom of the Ages and the Secrets of the Sages (Kitab'Uyun al-Haqa'iq wa Idah al-Tara'iq) is a thirteenth century Arabic book of sorcery, containing procedures pertaining to the manipulation of the laws of physics, burnt sacrifices, smoke, putrefaction, and many other magical operations. Thi

s book, previously unavailable in English, is an exemplar of the medieval magic of Syria, showing influences of alchemy, natural magic, demonology and ceremonial magic. The author has arranged the book into thirty chapters; each chapter describes sublime operations of a scientific and mystical natur

e, often described in allegorical terms. Its many described magical operations include the construction of magical rings and amulets, magical lamps, devices for divination, incenses, medicines, dyes, and commentaries on blood sacrifices. The compendium of formulae also contains extensive information

on plants, animals and minerals.

Smoke進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Smoke的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Starry Sky Adventures Arizona: Hike, Paddle, and Explore Under Night Skies

為了解決Smoke的問題，作者Ortiz, Isaiah 這樣論述：

Isaiah Ortiz is a water safety manager who travels the state for his day job and chases the Milky Way with his camera by night. Isaiah is a photography enthusiast, hiker and backpacker. He’s driven to show the world the beauty of star-filled skies in the interest of protecting it from the threats of

light pollution, wildfire smoke, and urban encroachment. Isaiah is a Sonoran Insiders influencer using social media to educate people on the importance of protecting wild spaces.

肉與海鮮製品中糖化終產物之方法開發與含量分析

為了解決Smoke的問題，作者林佑于 這樣論述：

近年許多研究發現，食物於熱加工過程中所進行之非酵素褐變中的焦糖化(caramelization) 與梅納反應 (Maillard reaction) 除了會產生香氛與色澤物質外，也會產生可能對健康造成危害之物質，如：丙烯醯胺 (acrylamide) 與雙羰基物質 (dicarbonyl species)。此反應中之中間產物雙羰基物質進一步會再與食品之蛋白質與脂質反應而形成糖化終產物 (advanced glycation end-products, AGEs)，如羧甲基離胺酸 (Nε-carboxymethyllysine) 與羧乙基離胺酸 (Nε-carboxyethyllysine)

。近來研究顯示飲食中的AGEs與許多慢性病具有正相關性，如糖尿病、肥胖、心血管疾病以及神經退化疾病。因此，本研究之目的在於探討不同加工方式對於肉與海鮮製品中糖化終產物生成之影響，並找尋食品中可以作為糖化終產物之指標物質。本研究首先利用高效液相層析串聯質譜儀成功開發同時檢測11種AGEs之方法，並具有良好之精確度與準確度。此外。本研究也針對食品中AGEs之前驅物以及加熱指標物質進行分析，包含lysine、arginine、雙羰基物質、furosine與lanthionine (LAN)。結果發現，氣炸加工方式與油炸方式相比可以顯著減少豬肉中AGEs及雙羰基物質之生成量。在市售罐頭食品的分析中，發

現其AGEs總量與總雙羰基物質、furosine、LAN、碳水化合物與糖含量具有顯著之正相關性。因此，本研究顯示氣炸加熱方式可以作為有效減少食品中AGEs生成之新穎性加工方式以及營養標示中的碳水化合物與糖含量有潛力可以作為快速鑑別食品中AGEs含量之指標物質。