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The Diaries of Franz Kafka

為了解決Expression的問題，作者Kafka, Franz 這樣論述：

An essential new translation of the author’s complete, uncensored diaries--a revelation of the idiosyncrasies and rough edges of one of the twentieth century’s most influential writers.Dating from 1909 to 1923, the handwritten diaries contain various kinds of writing: accounts of daily events, re

flections, observations, literary sketches, drafts of letters, accounts of dreams, as well as finished stories. This volume makes available for the first time in English a comprehensive reconstruction of the diary entries and provides substantial new content, including details, names, literary works

, and passages of a sexual nature that were omitted from previous publications. By faithfully reproducing the diaries’ distinctive--and often surprisingly unpolished--writing in Kafka’s notebooks, translator Ross Benjamin brings to light not only the author’s use of the diaries for literary experime

ntation and private self-expression, but also their value as a work of art in themselves.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Expression的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Denial and Co-Existence: Indigenous Peoples in Liberal Social Democracies

為了解決Expression的問題，作者Hocking, Barbara/ Havemann, Paul 這樣論述：

The main features of the book will be a detailed interdisciplinary description, analysis and critique of law, justice and power determining the contemporary relationship between Indigenous Peoples and the settler state in five liberal social democracies, namely Anglo-Commonwealth states of Australia

, Canada, New Zealand and the Nordic states of Norway, Sweden and Finland. The book will be breaking new ground by filling major gaps in the literature on the comparative political jurisprudence governing Indigenous-State. This book will be: the first book: that specifically identifies and illustrat

es the political-legal expression of the culture of denial of harm to Indigenous Peoples in the Anglo-Commonwealth and Nordic liberal social democratic states and that explores the barrier to just co-existence which denial constitutes; the first book: that specifically makes a comparative analysis o

f attempts to honour Indigenous Peoples' human rights in the context of their rights to self-determination and co-existence in these particular liberal social democracies; and We conclude, among other things: that the culture of denial is ubiquitous and pervasive in varying degrees; that denial prof

oundly impedes the impetus for institutional and constitutional redesign for co-existence between peoples, and that despite this impediment, political-legal institutions and processes are capable of change in the direction of promoting co-existence; that comparison of law, policy, institutional desi

gn, ideas about justice is vital knowledge for reflexivity and cultural transformation, for the crafting of good law, the fettering of power and for doing justice in the relationship between Indigenous Peoples, the settler state the dominant polity in these liberal social democracies.

資訊安全事件管理平台的自動化聯合防護阻擋機制之研究

為了解決Expression的問題，作者劉鍵毅 這樣論述：

隨著台灣資通安全意識提升，國內許多企業、法人或公務機關，逐漸重視資訊安全的防護，導入資訊安全事件管理平台，使網路活動及日誌可視化，並集中於同一平台上，讓資安管理人員能直接在SIEM平台上直接看見許多設備的日誌，平時除了能主動查找異常日誌外，也能被動地建立規則條件及門檻值（Threshold）使日誌被規則關聯。在有了告警功能後，管理者便可以一目了然的看見告警的原因，再經由人工判斷，判斷是否需要將該事件的IP新增到具有阻擋功能之設備進行阻擋，或向具阻擋功能之資安設備管理者申請阻擋。本研究將實作開發自動化聯防阻擋程式，並在資訊安全事件管理平台上建立相關規則，並利用模擬真實事件發生時的日誌，在資訊安

全事件管理平台上模擬出設備日誌，將資訊安全事件管理平台所觸發相關規則之事件IP，透過自動化阻擋程式，將IP送至入侵偵測防禦系統（Intrusion Prevention System, IPS）黑名單進行阻擋，以符合自動化阻擋機制，並將阻擋程式之日誌送至SIEM進行監控，最後將整體機制呈現於結果。